NTM Research Using the Latest Technology

When I spot a rat darting across the subway platform, my instinct is to sprint upstairs and flag down a cab.

Similarly, during my time living in a house in upstate New York, discovering mouse droppings nestled among my silverware was enough to trigger an all-out cleaning frenzy.

So, quite honestly, I have no affection for rodents and no qualms about their role in the testing of new drugs.

However, my perspective shifts when it comes to larger animals and scientific experiments. While I understand the necessity of involving larger animals in research, it saddens me. 

That’s why it’s reassuring to know that researchers like Dr. van Ingen and his team are developing alternatives to using lab animals, such as the hollow fiber model.

Traditionally, drug development relies heavily on animal models; however, these models often present limitations, particularly for NTM (non-tuberculous mycobacterial) research. 

For instance, according to Dr. van Ingen, mice do not naturally develop NTM pulmonary disease, which means researchers must compromise the mice’s immune systems. This artificial manipulation may not accurately predict human responses to treatments.

It’s hard to believe, but the hollow fiber model—a mechanism involving tubes, filters, and glass cartridges—can offer a more human-like environment for drug testing. By simulating the conditions found in the lungs, researchers can gain valuable insights into drug efficacy and potential side effects. This innovative approach has the potential to accelerate the development of effective treatments for NTM.

According to Dr. van Ingen, antibiotic safety is what matters most to him and his laboratory work focuses on ensuring that only the best antibiotics make it into clinical trials.

Click to learn more about Dr. van Ingen’s hollow fiber model, 

Thank you to NTM IR for sponsoring this talk. It may be one of your nerdiest discussions yet, but you’ve educated us well over the years, and many of us appreciate a deep dive from time to time!